Synthesis and characterization study on some metal complexes of schiff base derived from ninhydrin with S-methylhydrazine carbodithioate

Synthesis and characterization of Schiff base ligand of ninhydrin with S-methylhydrazinecarbodithioate and its Cr [III], Mn [II], Fe [III], Co [II], Ni [II], Cu [II], Zn [II] and Cd [II] complexes were reported. Elemental analysis, molar conductivity, magnetic moment, spectral 1H NMR, UV/Visible and IR data have been used to characterize these complexes. It has been found that the ligand behaves as mononegative ONS tridentate towards divalent metal ions forming 1:2 [metal:ligand] stoichiometry and as mononegative NS bidentate towards trivalent metal ions forming 1:3 [metal: ligand] stoichiometry. For all complexes, a non-electrolytic nature was observed. Some available spectral parameters were calculated. Octahedral and distorted octahedral geometries were proposed for the complexes on the basis of magnetic and spectral measurements

Enzymatic activation of the carcinogens 2 phenylethylhydrazine and 1,2 dimethylhydrazine to carbon centered radicals

Spin-trapping experiments demonstrate that oxidation of 1,2-dimethylhydrazine and 2-phenylethylgydrazine generates a comparable yield of carbon-centered radicals when catalyzed by horseradish peroxidase-H2O2. Using oxyhemoglobin as the catalyst, 2-phenylethylgydrazine oxidation generates ten times carbon-centered radicals than 1,2-dimethylhidrazine oxidation. This results is in agreement with oxygen consumption studies from which the apparent KM values of 8.0 mM and 72 mM were calculated for the oxyhemoglobin-catalyzed oxidation of 2-phenylethylhydrazine and 1,2-dimethylhydrazine, respectively. These differences in metabolic activation of mono- and disubstituted hydrazines may be of importance regarding the carcinogenic properties of these derivatives